SNORA50A: SNORA50A is a small nucleolar RNA, H/ACA Box 50A, with an unknown function [PMC6232700]. It has been found that the co-occurrence of IQGAP2 genomic alterations and the deletion in SNORA50A, SNORA50C, and RN7SK genes is associated with reduced disease-free survival in prostate cancer patients [PMC7336766]. A study by Xie et al. (2019) revealed that SNORA50A inhibits mRNA 3' processing by blocking the Fib1-poly(A) site interaction, which is the first report of snoRNA regulating mRNA 3' processing [PMC6629867]. In a study selecting twenty genes associated with prostate cancer progression, SNORA50A was among the genes identified [PMC8606581]. Interestingly, there were no SPOP mutations and copy number variations (CNV) for SNORA50A, SNORA50C, and RN7SK in a specific cohort of prostate cancer patients [PMC6232700]. The co-occurrence of CNV for SNORA50A, SNORA50C, and RN7SK with IQGAP2 genomic alterations suggests that noncoding RNAs may coordinate with IQGAP2 to suppress prostate cancer progression [PMC6232700]. Furthermore, these observed co-changes in IQGAP2 and snoRNA genes may have potential as a diagnostic tool for prostate cancer recurrence [PMC6232700]. Overall, while the function of SNORA50A remains unknown at present (PubMed), its involvement in genomic alterations associated with disease progression highlights its potential significance in prostate cancer research.